The aim of the news bulletin is to increase the awareness of adverse drug reactions amongst healthcare professionals, and to promote adverse reaction reporting to medicinal products. This issue includes topics such as reports of lack of efficacy with bupivacaine (Marcain®), rare reports of renal impairment with zoledronic acid (Aclasta®), post-marketing reports of severe liver injury with orlistat, intravascular haemolysis associated with WinRho® SDF injection and a summary on the findings of porcine circovirus DNA fragments in human rotavirus vaccines.